How is methadone different from heroin and other opioids?

Methadone lasts longer. The body metabolizes methadone differently than it does heroin or morphine. When a person takes methadone regularly, it builds up and is stored in the body, so it lasts even longer when used for maintenance. Most people find that once they're stabilized on a dose of methadone that is right for them, a single oral dose will "hold" them for at least a full 24-hour day. For some, the effect lasts longer and for others a shorter time.

Stability is easier on oral methadone. Most people who are on a stable, appropriate does of methadone for several weeks will not feel any significant sense of being "high" or "dopesick." Some patients may feel a "transition" or a temporary mild glow for a short time several hours after being medicated, however. Others may feel slightly "dopesick" prior to taking the day's medication, but most will feel very little or no effect from the proper dose of methadone once they have stabilized.